Journal Articles
64. H Zhang, T Rahman, S Lu, AP Adam and LQ Wan*, 2024. Helical Vasculogenesis Driven by Cell Chirality, Science Advances, 2024 Feb 23;10(8):eadj3582. doi: 10.1126/sciadv.adj3582.
63. T Rahman, F Peters, and LQ Wan*, 2024. Biomechanical Modeling of Cell Chirality and Symmetry Breaking of Biological Systems, Mechanobiology in Medicine, https://doi.org/10.1016/j.mbm.2024.100038.
62 . Z Hachem, C Hadrian, L Aldbaisi, M Alkaabi, LQ Wan, and J Fan, 2024 Asymmetrical positioning of cell organelles reflects the cell chirality of mouse myoblast cells, ALP Bioengineering, accepted.
61. H Zhang, J Fan, JMA Maclin, and LQ Wan*, 2023. The actin crosslinker fascin regulates cell chirality, Advanced Biology, e2200240, doi: 10.1002/adbi.202200240.
60. T Rahman, F Peters, and LQ Wan*, 2023. Cell Jamming Regulates Epithelial Chiral Morphogenesis, Journal of Biomechanics, 147:111435, doi: 10.1016/j.jbiomech.2023.111435.
59. B Hang, E Jassem, H Mohammed, and LQ Wan, JI Herschkowitz, and J Fan, 2022. Interacting with Tumor Cells Weakens the Intrinsic Clockwise Chirality of Endothelial Cells. APL Bioengineering, 6(4), 046017.
58. H Zhang and LQ Wan*, 2022. Cell Chirality as A Novel Measure for Cytotoxicity. Advanced Biology, https://doi.org/10.1002/adbi.202101088 (Journal cover).
57. H Zhang, K Ronaldson-Bouchard, G Vunjak-Novakovic, and LQ Wan*, 2022. A Micropatterning Assay for Measuring Cell Chirality. Journal of Visualized Experiments. https://www.jove.com/t/63105/a-micropatterning-assay-for-measuring-cell-chirality.
56. G Dai, AW Feinberg and LQ Wan*, 2021. Recent Advances in Cellular and Molecular Bioengineering for Building and Translation of Biological Systems. Cellular and Molecular Bioengineering, 14(4): 1-16.
55. H Zhang, J Fan, Z Zhao, C Wang, and LQ Wan*, 2021. Effects of Alzheimer’s Disease-Related Proteins on the Chirality of Brain Endothelial Cells. Cellular and Molecular Bioengineering, 14(3): 231-240. (Journal Cover).
54. T Rahman, H Zhang, J Fan, and LQ Wan*, 2020. Cell chirality in cardiovascular development and disease. APL Bioeng, 4 (3): 031503. (Highlighted in APL bioengineering newsletter)
53. AS Arabiyat, H Chen, J Erndt-Marino, K Burkhard, L Scola, A Fleck, LQ Wan, and MS Hahn, 2020. Hyperosmolar Ionic Solutions Modulate Inflammatory Phenotype and sGAG Loss in a Cartilage Explant Model. Cartilage, 1947603520961167, https://doi.org/10.1177/1947603520961167.
52. J Fan, H Zhang, T Rahman, DN Stanton, and LQ Wan*, 2019. Cell Organelle-based analysis of cell chirality. Communicative and Integrative Biology, 12(1):78-81.
51. L Miao, J Li, J Li, Y Lu, D Shieh, JE Mazurkiewicz, M Barroso, JJ Schwarz, H Xin, HA Singer, P Vincent, W Zhong, GL Radice, LQ Wan, ZC Fan, G Huang, and M Wu, 2019. Cardiomyocyte Orientation Modulated by the Numb Family Proteins–N-Cadherin Axis Is Essential For Ventricular Wall Morphogenesis. Proceedings of National Academy of Sciences, 116(31), pp15560-69.
50. M LV, Y Zhou, SW Polson, LQ Wan, M Wang, L Han, L Wang, and XL Lu, 2019. Identification of Chondrocyte Genes and Signaling Pathways in Response to Acute Joint Inflammation. Scientific Reports, 9(1): 93.
49. P Ray, AS Chin, KE Worley, J Fan, G Kuar, M Wu, and LQ Wan*, Intrinsic Cell Chirality Regulate Left-Right Symmetry Breaking During Cardiac Looping, Proceedings of National Academy of Sciences, pii: 201808052. https://doi.org/10.1073/pnas.1808052115.
48. AS Chin, KE Worley, P Ray, G Kuar, J Fan, and LQ Wan*, Cell Chirality Revealed By Three-Dimensional Spontaneous Rotation, Proceedings of National Academy of Sciences, 115(18), pp.12188-12193, https://doi.org/10.1073/pnas.1805932115.
47. A Abu-Hakmeh, AKM Fleck, and LQ Wan*, 2018. Temporal Effects of Cytokine Treatment on Lubricant Synthesis and MMP Activity of Fibroblast-like Synoviocytes, Journal of Tissue Engineering and Regenerative Medicine, epub ahead of print. https://doi.org/10.1002/term.2771.
46. KE Worley, AS Chin, and LQ Wan*, 2018. Lineage-Specific Chiral Biases of Human Embryonic Stem Cells During Differentiation, Stem Cell International, Vol. 2018, 1848605. https://doi.org/10.1155/2018/1848605.
45. J. Fan, P Ray, Y Lu, G Kaur, JJ Schwarz, and LQ Wan*, 2018. Cell chirality regulates intercellular junctions and endothelial permeability. Science Advances, 4, eaat2111. https://doi.org/ 10.1126/sciadv.aat2111.
44. KE Worley, J Rico-Varela, D Ho and LQ Wan*, 2018. Teratogen Screening with Human Pluripotent Stem cells. Integrative Biology, 10(9), pp491-501. (link)
43. J Rico-Varela, D Ho and LQ Wan*, 2018. In vitro Microscale Systems for Embryogenesis. Advanced Biosystems, 2 (6), 1700235. (link)
42. EY Sun, AKM Fleck, A Abu-Hakmeh, A Kotsakis, GR Leonard, and LQ Wan*, 2018. Cartilage Metabolism and Mechanics Modulated By Synovial Fluid Through Metalloproteinase Proteins, Annals of Biomedical Engineering, 46(6), pp810-818. (link)
41. J Li, L Miao, C Zhao, WM Shaikh Qureshi, D Shieh, H Guo, Y Lu, S Hu, A Huang, L Zhang, CL Cai, LQ Wan, H Xin, P Vincent, HA Singer, Y Zheng, O Cleaver, ZC Fan, and M Wu, 2017. CDC42 Is Required For Epicardial and Pro-epicardial Development By Mediating FGF Receptor Trafficking To The Plasma Membrane. Development, 144(9), pp1635-47. (link)
40. MJ Raymond, P Ray, G Kaur, P Haynes, M Fredericks, AV Singh, and LQ Wan*, 2017. Multiaxial Polarity Determines Individual Cellular and Nuclear Chirality, Cellular and Molecular Bioengineering, 10(1), pp 63-74. (link)
39. LQ Wan*, AS Chin, KE Worley, and P Ray, 2016. Cell Chirality: Emergence of Asymmetry From Cell Culture, Philosophical Transactions B, 371(1710). pii: 20150413. (link)
38. AE Abu-Hakmeh, A Kung, B Mintz, S Kamal, J Cooper, LX Lu, LQ Wan*,2016. Sequential Gelation of Tyramine Substituted Hyaluronic Acid Hydrogels Enhances Mechanical Integrity and Cell Viability, Medical & Biological Engineering & Computing, 54(12), pp. 1893-1902. (link)
37. MJ Raymond, P Ray, G Kaur, AV Singh, and LQ Wan*,2016. Cellular and Nuclear Alignment Analysis for Determining Epithelial Cell Chirality, Annals of Biomedical Engineering, 44(5), pp.1475-86. (link)
36. X Chen, Y Zhou, BK Zimmerman, L Wang, MH Santare, LQ Wan, and XL Lu, 2016. Determining Tension-Compression Nonlinear Mechanical Properties of Articular Cartilage from Indentation Testing. Annals of Biomedical Engineering, 4(4), pp.1148-58. (link)
35. AKM Fleck and LQ Wan*, 2015. Magnetic Resonance Imaging of Healthy, Diseased, and Regenerated Cartilage, Current Tissue Engineering, 4(2), pp. 111-121. (link)
34. Y Zhou, MA David, X Chen, LQ Wan, RL Duncan, L Wang and XL Lu, 2015. Effects of Osmolarity on the Spontaneous Calcium Signaling of In Situ Juvenile and Adult Articular Chondrocytes. Annals of Biomedical Engineering, 44(4), pp.1138-47. (link)
33. J Xie, T Owen, K Xia, AV Singh, E Tou, B Arduini, H Li, LQ Wan, B Callahan, and C Wang, 2015. Zinc Inhibits Hedgehog Autoprocessing: Linking Zinc Deficiency with Hedgehog Activation, J Biol Chem, 290(18), pp.11591-600. (link)
32. KE Worley, D Shieh, and LQ Wan*, 2015. Inhibition of Cell-Cell Adhesion Randomized Epithelial Chiral Morphogenesis on Micropatterned surfaces, integr Biol, 7(5), pp. 580-90.(link)
31. AV Singh, M Raymond, F Pace, A Certo, JM Zuidema, CA McKay, RJ Gilbert, XL Lu, and LQ Wan*, 2015. Astrocytes Increase ATP Exocytosis Mediated Calcium Signaling in Response to Microgroove Structures, Scientific Reports, 5: 7848. (link)
30. S Bhumiratana, RE Eton, SR Oungoulian, LQ Wan, GA Ateshian and Vunjak-Novakovic G, 2014. Large, Stratified, and Mechanically Functional Human Cartilage Grown in vitro by Mesenchymal Condensation, Proceedings of National Academy of Science, 111(19), pp. 6940-5. (link)
29. AE Abu-Hakmeh AE and LQ Wan*, 2014. High-Throughput Cell Aggregate Culture for Stem Cell Chondrogenesis, Methods Mol Biol, 1202:11-9. (link)
28. AV Singh, KK Mehta, K Worley, JS Dordick, RS Kane, and LQ Wan*, 2014. Carbon Nanotube-Induced Loss of Multicellular Chirality on Micropatterned Substrate Is Mediated by Oxidative Stress, ACS Nano, 8(3), pp. 2196-205. (link)
27. YS Zhang, A Sevilla, LQ Wan, IR Lemischka, G Vunjak-Novakovic, 2013. Patterning Pluripotency in Embryonic Stem Cells, Stem Cells, 31(9), pp.1806-15.(link)
26. LQ Wan*, K Ronaldson, M Guirguis, and G. Vunjak-Novakovic*, 2013. Micropatterning of Cells Reveals Chiral Morphogenesis, Stem Cell Research and Therapy, 4:24-31. (link)
25. K Worley, A Certo, and LQ Wan*, 2013. Geometry-Force Control of Stem Cell Fate, BioNanoScience, 3(1), pp. 43-51.(link)
24. NT Khanarian, J Jiang, LQ Wan, VC Mow, and HH Lu, 2012. A Hydrogel-Mineral Composite Scaffold for Osteochondral Interface Tissue Engineering, Tissue Engineering, 18(5-6), pp. 533-45.(link)
23. T Zhang, LQ Wan, A Marsano, R Maidhof, and G Vunjak-Novakovic, 2012. Chitosan-Collagen Based Channeled Scaffold for Cardiac Tissue Engineering, Journal of Tissue Engineering and Regenerative Medicine, 6(9), pp.748-756.(link)
22. LQ Wan and G Vunjak-Novakovic. Micropatterning Chiral Morphogenesis, 2011. Communicative & Integrative Biology, 4(6), pp. 748-756.(link)
21. Y Duan, Z Liu, J O'Neill, LQ Wan, DO Freytes, G Vunjak-Novakovic, 2011. Hydrogel Derived from Native Heart Matrix Induces Cardiac Differentiation of Human Embryonic Stem Cells Without Supplemental Growth Factors, Journal of Cardiovascular Translational Research, 4(5), pp. 605-15.(link)
20. LQ Wan, K Ronaldson, M Park, G Taylor, Y Zhang, JM Gimble, and G Vunjak-Novakovic, 2011. Micropatterned Mammalian Cells Exhibit Phenotype-Specific Left-Right Asymmetry, Proceedings of National Academy of Science, 108(30), pp. 12295-300.(link)
19. LQ Wan, J Jiang, DE Arnold, XE Guo, VC Mow, and HH Lu, 2011. Matrix Deposition Modulates Viscoelastic Shear Properties of Hydrogel-Based Engineered Cartilage Tissue, Tissue Engineering Part A, 17(7-8), pp.1111-22.(link)
18. AF Godier-Furnémont, TP Martens, MS Koeckert, LQ Wan, JJ Parks, K Arai, G Zhang, BJ Hudson, S Homma, and G Vunjak-Novakovic, 2011. Composite Scaffold Provides A Cell Delivery Platform For Cardiovascular Repair, Proceedings of National Academy of Science,108(19), pp. 7974-9.(link)
17. N Tandon, A Marsano, R Maidhof, LQ Wan, H Park, and G Vunjak-Novakovic, 2011. Optimization of Electrical Stimulation Parameters for Cardiac Tissue Engineering, Journal of Tissue Engineering & Regenerative Medicine, 5(6), pp.115-25.(link)
16. LQ Wan, SM Kang, G Eng, WL Grayson, XL Lu, B Huo, J Gimble, XE Guo, VC Mow, and G Vunjak-Novakovic, 2010. Geometric Control of Adult Human Stem Cell Morphology and Differentiation, Integrative Biology, 2(7-8), pp. 346-53.(link)
15. A Marsano, R Maidhof, LQ Wan, Y Wang, J Gao, N Tandon, and G Vunjak-Novakovic, 2010. Scaffold Stiffness Affects the Contractile Function of Three-Dimensional Engineered Cardiac Constructs, Biotechnology Progress, 26(5), pp.1382-90.(link)
14. XL Lu, LQ Wan, XE Guo, and VC Mow, 2010. A Linearized Formulation of Triphasic Mixture Theory for Articular Cartilage, and Its Application to Indentation Analysis, Journal of Biomechanics, 43(4), pp. 673-9.(link)
13. WL Grayson, M Fröhlich, K Yeager, S Bhumiratana, C Canizzarro, LQ Wan, E Chan, X Liu, XE Guo, and G Vunjak-Novakovic, 2010. Engineering Anatomically-Shaped Human Mandibular Bone Grafts, Proceedings of National Academy of Science, 107(8), pp. 3299-304.(link)
12. LQ Wan, XE Guo, and VC Mow, 2010. A Triphasic Orthotropic Laminate Model for Cartilage Curling Behavior: Fixed Charge Density vs. Mechanical Properties Inhomogeneity, Journal of Biomechanical Engineering, 132(2): 4504.(link)
11. DO Freytes, LQ Wan, and G Vunjak-Novakovic, 2009. Geometry and Force Control of Cell Function, Journal of Cellular Biochemistry, 108(5), pp. 1047-58.
10. TP Martens, AFG Godier, JP Parks, LQ Wan, MS Koeckert, J Ifkovits, JA Burdick, W Sherman, and G Vunjak-Novakovic, 2009. Catheter-Based Delivery and In Situ Polymerization of Cell-Hydrogel Suspensions, Cell Transplantation, 18(3), pp. 297-304.
9. M Fröhlich, WL Grayson, LQ Wan, D Marolt, M Drobnic, and G Vunjak-Novakovic, 2008. Tissue Engineered Bone Grafts: Biological Requirements, Tissue Culture and Clinical Relevance, Current Stem Cell Research & Therapy, 2008, 3 (4), pp. 254-264.
8. LQ Wan and VC Mow, 2008. Cellular and Molecular Biomechanics: the Articular Cartilage Paradigm — A Review, Journal of Medical Biomechanics, 23(1), pp. 1-18.
7. LQ Wan, J Jiang, DE Arnold, XE Guo, HH Lu, and VC Mow, 2008. Calcium Concentration Effects on the Mechanical and Biochemical Properties of Chondrocyte-Alginate Constructs, Cellular and Molecular Bioengineering, 1(1), pp. 93-102.
6. LQ Wan, C Miller, XE Guo, and VC Mow, 2004. Fixed Electrical Charges and Mobile Ions Affect the Measurable Mechano-Electrochemical Properties of Charged-Hydrated Biological Tissues: The Articular Cartilage Paradigm, Mechanics & Chemistry of Biosystems, 1(1), pp. 81-99.
5. LQ Wan, ZY Han, L Yang, and C Wang, 2003. An Investigation of Far-Atomization Field Under the Condition of Axisymmetrical Dissemination and Breakup of liquid with constraints, Journal of Experimental Mechanics (in Chinese with English abstract), 18(4), pp. 452-457.
4. LQ Wan, ZY Han, QJ Cai, and JC Yao, 2001. Investigation on Measurement of the Sauter Mean Diameter of Particles in the Atomization Field Using Laser Scattering Method, Explosion and Shock Waves (in Chinese with English abstract), 21(4), pp. 248-252.
3. QJ Cai, ZY Han, LQ Wan, and SQ Zhang, 2000. Investigation of Later Period of Primary Breakup in Axisymmetric Dissemination of Liquid Ring: Experiments and Measurements in Fluid Mechanics, Explosion and Shock Waves (in Chinese with English abstract), 14(1), pp. 57-62.
2. QJ Cai, ZY Han, LQ Wan, and SQ Zhang, 1999. Investigation of Basic Behavior of Atomization Region Formed by Secondary Breakup of Liquid Ring. Experiments and Measurements in Fluid Mechanics (in Chinese with English abstract), 13(2), pp. 22-29.
1. QJ Cai, ZY Han, LQ Wan, and SQ Zhang, 1999. Calibration of Measurement System and Investigation of Size Behavior of Atomization Region Formed by Secondary Breakup of Liquid Ring. Explosion and Shock Waves (in Chinese with English abstract), 19(2), pp. 151-157.
Book Chapters
3. VC Mow, XL Lu, and LQ Wan, 2011. Rigorous Mechanics and Elegant Mathematics on the Formulation of Constitutive Laws for Complex Materials: An Example from Biomechanics, From Waves in Complex Systems to Dynamics of Generalized Continua – Tributes to YIH-HSING PAO on His 80th Birthday, K. Hutter et al eds., World Scientific Publishing Company, Singapore, pp. 285-306.
2. LQ Wan, XE Guo, and VC Mow, 2009. The Origin of Pre-Stress in Biological Tissues − A Mechano-Electrochemical Model: A Tribute to Professor Y-C. Fung, Tributes to Yuan-Cheng Fung on His 90th Birthday: Biomechanics, from Molecules to Man, S. Chien et al eds., World Scientific Publishing Company, Singapore, pp. 21-30.
1. AJ Troken, LQ Wan, NW Marion, VC Mow, and JJ Mao, 2006. Properties of Cartilage and Meniscus, The Wiley Encyclopedia of Medical Devices and Instrumentation, J.G. Webster, eds., Wiley-Interscience, New York, NY, pp. 63-80.